Have you heard of Remus Sirion? He has a lot of natural looking facial features. I'll link you straight to his navigation. Might take a minute to load, as his stuff is high quality. His skins aren't too bad. I only use his male fantasy skin for male vampires though.
https://remussirion.tumblr.com/navigation
Most skins I find online don't look well in-game (even with HD installed). There's a good male and female skin I found by Ms Blue on TheSimsResource. They are called Markus for the male and Mirabelle for the Female. You can check out her work here:
https://www.thesimsresource.com/artists/Ms_Blue
I don't have any clothing recommendations. Like you, they've all ended up looking wonky in-game as well. I use default/game clothing.
Sorry I can't help much more. I don't get into CC that much. I only use a few things and I'm good.