If I'm not mistaken, it should be an option to add to the cleaner, which would effectively automatically remove vampire status from any randomly generated sims.
In my personal experience, the game itself doesn't really generate vampire sims automatically (or if it does, it's so infrequent that it's unnoticable), so even if that's not the case, you should only need to do it once. It doesn't delete the sims themselves, just makes them human (Vladdy included). You should be able to use MCCC to disable vampire scenarios (which is the only thing I can think of that would cause the game to generate a new vampire sim), which should ensure that you never have to deal with vampires again (unless you were to change your mind and create a vampire on purpose).
