Can sims 4 custom content/sims 4 in general cause blue screen of death crashes?

@robbxe I suppose it's possible but not likely. I've never seen it happen myself. The best way to test to make sure is to move your entire Mods folder somewhere else and remove it from your game and try it without mods. If it still crashes, it's not the mods.

It might be best to try a game repair in origin and check out your graphic settings, they might be too high.