Can you play sims 4 with an external hard drive?

I had originally played the game on my 2014 MacBook, but then, because my HD had too little storage, I loaded my macOS to a WD 4TB EHD and created a User account on it. On that User account I was able to download and play Sims 4 AND Parallels. The startup runs VERY slow IF I have massive mods like Arnie’s World Edit, but with that gone my game loads and plays w/ 3k mods just fine. W/ World Edit my game took, like, SIX HOURS to load! Hahaha so, yeah. Without THAT mod you should be just fine.😉

****EDIT*** I have since purchased a new 2T Samsung 7T external hard drive (EHD) and it works SO much smoother! I can run my game w/ 3k+ mods and on Ultra and the game loads in less than 6mins.! IT'S AMAZING!