Game failed to load, please help.

@Girliegooner1 

@YuvalShmueli7 

@Dejareese 

After each update, most scripts mods and a large part CC will be spoiled and will spoil the game. Checking what broke down this time after the patch, and replacing these broken ones by a new updated version or deleting these is the price the player pays for using CC and mods. Removing mods isn't enough
Move the mods folder to the desktop.
Delete localthumbcache.package file in the game, also delete all folders with the word "cache" in the name - important!
Fix the game in Origin.
Origin/Library - right-click on TS4 - option "Repair game"
You have to wait until Origin will fix all packs, not only the base game.
Turn on the game to create a new, empty mods folder and check if a game is working now without mods and CC.
Check if there are new updated versions of the mods and CC you are using.
Then copy from desktop your mods and CC and paste it in the new mods folder. First, paste script mods one by one every time checking if the game is OK. You can start with UI Cheats Extension mod because it will always be broken after the patch
Do the same with CC but if you have a lot of this, try the 50/50 method. ( divide your CC into smaller batches for example 50 pieces in one subfolder and check these subfolders one by one)

You need to find culprits and either remove them or replace it with updated versions.

If you don't have mods delete this file and folders and fix the game also

About  "I can't click on something"  - if it is Main Menu or CAS change the resolution setting in the game options. Try different - the highest first.

I don't work for EA