@hinckleyan Within the SentinelOne settings, please specifically set path exclusions for the Origin and Origin Games folders in Program Files (x86), using the "Performance focus - extended" option described here:
https://www.cybervigilance.uk/post/sentinelone-path-exclusion
(Check the box to include subfolders too.) I don't know whether this is necessary for Sims 4, but it's easiest to start with the most sweeping option and work backwards from there.
If that doesn't help, temporarily disable SentinelOne entirely. As long as you don't do anything except open Origin and Sims 4, your computer should be safe. Again, I'm not saying this is the best permanent fix, just a useful way to narrow things down.
If that doesn't help either, please create a new admin Windows account on your computer. The account name should contain only letters and numbers, no special characters, accents, etc. Make it a local account, as in, don't sign into your Microsoft account, and don't sync with any other services. You'll be able to sign into your existing Origin account and shouldn't need to redownload anything, but your saves and other user content won't be available. Just let me know whether you can launch the game and create a new save.