What unusual settings have you changed from default

Cool settings there @PsyhiX69 

I only swapped space and E around. Because on my left hand I like to tap the space bar with my thumb to loot.  W and E are very close and make movement keys close to each other.  I might make Q crouch later.   To recap my settings;

E - jump

Space - loot / interact

Q - crouch (to be set in the next game)

C - swapped with Q of course.

Great topic!

After some more thought on my personal finger reach on the keyboard and the fact that I am left handed, this was my solution;

Top Row Changes

1 - Tactical 

2 - Ultimate 

3 - Utility ( really didn't understand the description ) this is used by Crypto to call his drone back.

Movement Keys

Q - Crouch

E - Jump

Miscellaneous 

H - Holster weapon

Space - Loot

1 and 2 are swapping weapons and I use the mouse scroll to cycle.  Thus I blanked the individual choices of weapon 1 and weapon 2 freeing up 2 keys. H makes sense for holster.  I can now rest my 3 center fingers on Q, W, E as I seldom use A, S, D combat movement keys. My pinky finger on shift for sprinting and thumb on space for looting.  I have only been active in the game for 3 to 4 weeks, but muscle memory needs to be retrained.  If you decide to make your own custom layout, go in solo or train in the firing range as I did all day yesterday.  You don't want to be pressing the old buttons with your friends and such in Arenas and BR saying, "Oops!" and "Sorry about that!".

Everything else in settings is mainly reducing GPU for better FPS, beware that a person running 1080p is going to be "more perceptive" than a player at 720p.  Reducing shaders and extra lighting effects is going to improve your performance.  Audio not much there to discuss, however try not to listen to your character's ranting about the ring closing.  The game is psychologically trying to rush you at all times into the throat of danger.  Unless you are ready and looking for a fight, stay in the outer ring and loot as much as you can.