GPU: GTX Titan @ 344.75 drivers
CPU: Core i5 3570k
RAM: 8GB
Resolution: 1440p
I just finished the tutorial with everything set as high as possible except for MSAA, which was turned off. I was getting around 30 - 40 FPS in combat and anywhere from 10 - 35 FPS during cutscenes (I have -GameTime.MaxSimFps 60 -GameTime.ForceSimRate 60+ set).
I don't mind the 40 FPS in combat, but the cutscene FPS is pretty unbearable. The lowest parts seemed to be during cutscenes invloving fire and/or fade rifts. However, as soon as I excited the cut scene, my FPS climed back up.
Turning any of the settings that don't require a restart from Ultra to Low barely affected things, and I didn't have the patience to keep relogging to try others. I did set it to automatic, but that did nothing to help. Going down to 1080p did nothing, either. Fullscreen, windowed, fullscreen windowed, no change. Vsync, no change on or off.
Now that I'm done with the tutorial, I'm in an area where there are about 60 NPCs all in a row (literally the first thing you see after the tutorial). My FPS drops to about 23 here, though this might not be the best place to judge performance. Where should I go to start trying to mess with settings for a good "average" load?