Car Setups should be "centered"
I don't think I need to say a lot. Every track is using the same setup. Besides wing-setting, the most adjusted setting is Front Brake Bias!
100-25 Diff, Camber/Toe all left, Suspension Front hard, Rear soft, ARB front soft, rear hard, always same Ride Heigt (21-43), Tire Pressure front hard, rear soft.
My (obvious) solution: Whatever the most negative camber effects are, put it in the middle and extent the values so you can make the setup more aggressive. Whatever the most stiff front suspension is, put it in the middle and let us make it harder. And so on.
The current problem is that there is no "leeway" or personalization within setups, when the "best base setup" for each track already would want to go beyond the limit of what is possible to one direction. Everything else is just borderline undriveable. And no, sadly tire wear isn't a relevant factor that would change setups for the race all that much. At most you'd change tire pressure or downforce, but more for better grip under non-optimal conditions than tire concerns.
F1 20 - 23 I spent a lot of time on setups and it felt like different settings for different tracks actually made.. a difference.