Controls stop responding (And physics/crash issue)

I'm playing Mass Effect 1 that I downloaded with Origin but I'm having some issues. The main one is that sometimes after a conversation or after I open and close the pause menu the controls stop responding. The mouse doesn't move, the movements keys to nothing and pressing Esc make a 'beep' noise like the game recognises it's been pressed but doesn't do anything. The game still runs but I have to Alt+Tab out and manually shut down the game in the task manager.

Another issue that does cause a crash that happens on rare occasions is that I'll kill an enemy but after combat they'll stand back up in an idle animations...and so I shot it, then the game crashed. I didn't get an error message when the crash happened the game just shut down. Another (but different issue) happened when I used the Lift power on a Husk on Eden Prime at the Spaceport, as soon as it hit the floor the game crashed, something to do with a missing collision file (admittedly I only had this problem one time).

The last issue is that very rarely after a conversation Shepard won't move, the controls respond but he won't move from the sport. This occurred when speaking to Morlan during the Dr.Micheal quest, after I left the conversation I had one stuck Shep.

I'm playing the game on Windows 10, I have tried using Origin's repair function without success, I've tried running Origin with the Overlay turned off, I've tried running Origin in offline mode. I've run the game as Admin and I've run it in Compatibility Mode WinXP Service Pack 2 and 3. I have a GTX 560ti with a i7 3930k 3.20ghz CPU, 16GB of RAM, my drivers are up to date and I have the Nvidia Legacy Drivers installed. It worked fine back on Windows 7, I really just want to be able to go through the trilogy again but trying to get passed ME1 is becoming a chore since I can't even seem to make it passed the Citadel without running into issues.