I have tried...
EA App (running on startup) launching ME:A through the App
EA App (running on startup) launching ME:A from the desktop shortcut
EA App (running on startup) launching ME:A as Admin (right click) from the desktop shortcut
Closing the App and Re-launching the app as admin (right click), running ME:A through the EA App
Closing the App and Re-launching the app as admin (right click), running ME:A from the desktop shortcut as admin (right click)
Closing the App and Re-launching the app as admin (right click), running ME:A from the The Directory as admin (right click)
Closing the App and Re-launching the app as admin (right click), running ME:A from the The Directory set run as admin (properties>Compatibility>Run as Admin)
And for good measure I tried (run as admin)...
running in Compatibility mode for windows 8
running without a microphone (steam suggestion)
deleting App data
changing the dir in reg edit
and re-installing
If I had just bought it I would have asked for a refund but I got it back in 2017 so I have just over 100 hours from my first play through(s)... do you think there might be a version issue? The App installed Deluxe Edition and Deep Space Pack, I assume it comes standard now but I don't remember buying any extra content 7 years ago
And to add some confusion I can't run Dragon Age Inquisition after failing to run ME:A, I need to close the app and (task manager) end task EA background services then run DA:I from the desktop and let the shortcut launch the EA app or it fails to run as well.