I skipped most of the bs misc go find me quests on the two runs I so far have completed, and both took about 60 to 65 hours and reached level 62.
First play was Vanguard/mostly on Normal.
Second play was Infiltrator/mostly on Hardcore.
It all depends on how much you wish to explore, most exploration is not mandatory and you can just focus on main quest which I believe takes perhaps 20 hours to complete, maybe less. If you do everything I would estimate about 110-130 hours.
It would depend on if you made a direct run through the main missions, spent some time doing the ones you think will be essential in the future, or try to go completionist and finish every possible quest.
I spent about 50 hours on the first playthrough and did not spend much time on obvious fetch/collection quests or worrying about mining setups. Didn't spend a lot of time crafting, mostly only crafted when I no longer was killing things and instead they were killing me. Ended it for level in the mid 50's. Beelining it you could shave quite a bit of time off that, going completionist you could add quite a bit as well.
