Re: Mass Effect 2 - Physx error
Uninstall the version of the PhysX software you have from "Programs and Features" inside the Windows control panel. (if you don't have a PhysX software installed you can skip this part.)
reboot.
Then go to your ME2 Game folder > redist > and run the "PhysX_9.09.0814_SystemSoftware.exe."
reboot
That should fix the problem. Should it not, please report back.