Crashing to Desktop June 2025

Kissyalove14​  It's definitely possible that you have multiple completely separate issues here.  Reshade was (probably) the reason the game crashed in a clean user folder, and there's also something in your main user folder that's a problem.  So now that the game is stable with no added content, you can start testing your old content in the new user folder.

Your CPU and GPU usage looks fine, by the way, a bit low but not necessarily in a problematic way.  I think it's clear that the crashing wasn't coming from your hardware.

I would start with testing your mods.  NRaas mods are likely fine, so try the rest in batches, and split and retest any batch that gives you trouble until you find the culprit.  Then move on to your custom content, and then transfer your saves.

I would also strongly suggest not merging mods at all, or downloading fresh copies if you've already merged some.  Having merged mods makes troubleshooting more complicated and can also sometimes break the mods.  On the flip side, you're not helping the game all that much by merging mods (as opposed to cc) until you get to such a high number of mods that you're likely to run into problems due to the sheer number.  Point is, there really isn't a safe zone where your mods collection is under control but you'd see a worthwhile improvement from merging them.

Custom content is a different matter, since collections can get relatively large without completely tanking game performance.  But I'd still keep the originals somewhere for those times when you need to track down bad cc, or a merged file appears to be corrupted, or you want to do a refresh without having to download everything from scratch.