This would be so cool! In the beginning, when creating your sim, you could give them a disease or defect at birth or somewhere is the settings be able to turn it off. You could make them have cancer, ...
I agree with the idea of diseases. To calm down haters of this idea, what if instead real life diseases, be non-real ones? Get To Work ills are quite easy to cure and even if you no take medicine, it is cured by time. They should advance if no cured or you take action to mitigate it. Even reach a point where it turns into fatal diseases
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