Strangerville help

Wow, so, it's been a couple of updates since I did it, but...

I always go in fast and hard. No "be careful," no "take a breather," just hit her as hard as I can as fast as I can.

I don't know if there's been a change that affects that, but that's what always works for me. Well. I did have an issue when I used Caleb Vatore and he did his vampiric run and his allies arrived right around the time Mother smacked him on the ground, but... since then I also always call the allies, add them to a group, "go here together" until they're standing in front of the door together and THEN open the door and choose to fight the mother...

I just beat the mother two days ago. I had no problem. I only had one vaccine to throw at it too. Not sure if it’s just luck or what. But I also had almost maxed out relationships with the three sims I had fighting with me. So maybe that has something to do with it? I also didn’t take any breaks or stand down or whatever. Like the other commenter said I just go hard and fast at it. 

So, I replayed the boss fight in Strangerville last night. Rather than using cured townies, I used my Sim's three housemates, so they had a high relationship.

Going in fast and hard did seem to be the best strategy again, and I defeated Mother on the first try. I only had one vaccine to throw at her and I did that as the first action, and then it was CHARGE CHARGE CHARGE!!!

I hope that helps!