After update, my Sim have forgotten all family, friends, and pets!

Have you tried to rollback the save?

https://help.ea.com/en/help/the-sims/the-sims-4/how-to-restore-a-previous-saved-game-in-the-sims-4/ here's a guide from EA that might help.

@MzRoadRunna do you have any backups of your save? If so, her relationships should still be intact in the backup save. Try copying it to your sims 4 folder. If you don't have any backups, the game automatically makes them. Just press the little save icon with a circle arrow on the load game screen and select one of the recovery saves.

https://i.imgur.com/0gJhTak.png

Edit: just another thought I had. Do you have get to work? If so, an alien may have erased her memory. Try rolling back the save and see if she remembers.

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