I suppose it depends on where you imagine San Myshuno to be. For my part, I don't think of San Myshuno as an American city. I know that the designers were influenced by American cities like San Francisco, but to me San Myshuno just does not look American. The upmarket areas are just too uniformly new-looking. If this were a major American city, I would certainly expect to see some futuristic architecture, but the new would be interspersed with the old.
To me, San Myshuno speaks of a city that started off on a fairly modest scale, but then experienced a sudden burst of growth and prosperity, obliging the planners to create a whole new, completely modern downtown area across the bridge from the old downtown area. Admittedly, there are many cities that might fit this profile, but not New York (or San Francisco, for that matter). I prefer to think of San Myshuno as an (imaginary) eastern city, with a backstory something like a cross between Hong Kong and Dubai. That being the case, the ethnic mix of the population works very well for me.