I always play with autonomy on but don't leave My families to their own devices until I've trained them up a bit.
They all have to have their own beds assigned to them from the start, with lucky Sims who get a double bed to themselves, having both sides assigned to them to stop another member of the family getting in with them.
Never start off with a pool, tent or a barbecue in the garden. Sims will start off by swimming, sleeping in the tent or burning themselves to death on the barbecue because they haven't got the proper skill to use it. Stop the kids from using a computer by limiting it to the adults for a bit.
Always start off with what the Sims basically need and not what I would like them to have. This is what I learned from the first Sims Game and it still stands with this one.
You have to have the right house, one that is right for them and doesn't entail them going upstairs to wash the dishes or not use the dishwasher because they are in the wrong place. There's a lot of satisfaction in seeing your Sims clearing the table and putting the plates in the dishwasher without being asked and seeing the children actually opting to do their homework is a bonus. The simpler the house layout the better and plenty of room to get around without being stuck.
Get your Adult Sims a job, with one doing it from home, Others having to go out. A butler, nanny or maid can help if affordable.
I like to leave my Sims going on with their lives whilst I make lunch etc and it's a great bonus to come back and see they are keeping all their needs in the green and no one dead!
I can then leave them to flourish and rotate to a new family. I usually meet the old families in the Diner, cafe or bar etc. to socialize with later.