I actually like some of the nerf-perks. Vain stopped working not long after I got it and it doesn't do anything any more, no debuff. The food-related one isn't an issue because my sim is high in cooking. The Stan isn't an issue because I keep the house and gates locked.
The famous rub-elbows one is a real problem though. You have to interact with someone MORE famous than you. As you grow in fame, it gets harder and harder. Once you reach Global Superstar, you pretty much have a permanent debuff. If I get that perk, I usually reset my fame 'cause I'm basically screwed then.