I like doing the negative ones on purpose. I find them much harder to get than positive ones sadly. I think I've done all except uncontrolled emotions. I usually like my sim to have two positive ones and one negative, of course with some variation. Irresponsible is really fun and there's a real change they get fired from work. Insensitive hasn't done much for me... it's some extra interactions but perhaps I don't play my sim enough that way. I haven't noticed any autonomy related to it. I don't remember if it's bad manners or argumentative but there's been some trouble starting relationships which is nice to play for a change.
Carl's Sims 4 Guide has good info about all the character value traits:
https://www.carls-sims-4-guide.com/gamepacks/parenthood/values.php