I resorted to locking the doors on all greenhouses to stop random Sims from bothering the bees. Only my top-level gardeners are allowed to go into the greenhouses. And don't try to calm the bees if your Sim's fun level is not green. It doesn't need to be maxed out, just not low. I have had better success with calming and bonding if my Sims are happy and their motives are high. A fun thing to note is the fact you can see the mites jumping around on the floor at the base of the aviaries. Once the mite treatment is applied the mites on the ground and on the bee box disappear. During the winter the bees do hibernate and don't seem to get enraged as often so they are much easier to bond with. However, that doesn't mean my Sims don't get their fair share of bee stings. Befriending bees is a long process.