Stopped using cc and mods since Seasons
then again I was never heavy user I just had some gameplay mods and few cas and bb things
personally I find the game more fun vanilla because indeed no mod worries therefore less fearing for my save everytime theres update
also this challenges me to play with whole game instead of just playing with the small subset of favourite things over and over
then again I did have to start new save anyway since my old one was broken so I probably would recommend to time the switch to when you are looking to start new save cause it will make total mess of saves using the said cc and mods
or indeed just taking the mod folder and related saves out of your game folder
starting with new save and seeing if you like it or not
there have been times I have considered say adding cool witch hat to my game or adding certain gameplay mods
but ultimately I find that I would much rather keep my beloved save than those additional things