It is not strictly never, but I actively avoid vacations and active careers. Vacations because I don't like it being tied to the vacation day system. I like the idea of it, but it is more for a random vacation day at home. When tied to my actual vacations it limits my trips and is just a general nuisance. It isn't even necessarily that realistic because with most employment you can schedule a proper vacation period well ahead. So I miss the vacation from the old games where time does not really move when you leave the residential world.
As for active careers, I can enjoy them, but sometimes I just want to focus on other things. Not to mention I usually have full households, so good luck keeping up with multiple active careers. I can send them alone, but I need to tag along to get their promotions. Or at least the last time I played an active career proper. I like owning businesses a lot more.