Started and completed the No Skills No Problem scenario last night. Never realized what a handicap it could be to not be able to gain and improve skills, it was torture watching a whole garden glitter and not being able to evolve the plants because my sim couldn't get the Gardening skill. Once I ditched my initial plans to garden and collect my way to to the 400000 Simolean goal and started selling the highest price cameras on a street sell table at 300% markup I completed it in 14 days.
Thinking about trying this scenario in Jungle Adventure, with all the traps working off various skills (and attacking swarms) it's going to be more like how long before the sim dies than if they manage to make the scenario's goal.