I was playing them in my pre-made save recently.
Jess is still infected and just gave birth to her second daughter. Dylan is in denial that she's even infected. He took up the doctor career (maybe to find out more about his wife's possible illness?), so he's no longer a stay-at-home dad, but he's still heavily involved in raising the children. He does try and snap Jess out of it when he catches her exhibiting symptoms, but usually she just wanders around the neighborhood at night talking to plants or bothering Erwin at his booth. When the children are teens, I think they're going to team up and try to cure her/defeat the mother, maybe Dylan will finally come around and help them too, but I haven't decided yet.
