Depends what you mean.
Exiting without restart: Only in 2 circumstances: 1) Sim that I wanted around died, or 2) Game crashed.
Starting in a new save: Ran out of lots to build on, needed new "no custom content" save for game update, mods used in old save became obsolete, had to remove some bad content that kept my game from loading (Sims 4 and Sims 2 ".package" files have the same file extension so it is difficult to tell them apart especially new Sims 2 downloads), or new scenario available. Shame we don't have a package file troubleshooter that will tell us which game the package works with. I have started using Sims4Studio just to preview the content when the game is not running: if it will display when loaded in S4S, it is a legit Sims 4 file...but this does not work for script mods or merged files. (I love those batch fixes that fix old cc as well.) I rarely play vanilla games.