So, just to update everyone, I did a little test with my game.
Leaving everything as it was (using mods EXCEPT MCCC, which has been taken out. I don't use any turbodriver mods.), I started a brand new save file with a newly created household. As soon as I placed the household into an empty lot in Willow Creek, I tried saving to confirm if the bug was still happening - it was. As always, I was unable to save it, and got the annoying error message.
I exited the game. Then, I used the advanced game options in Origin to disable the High School Years pack as suggested. I didn't change anything else, nor did I remove or add in any new mods, CC, etc. I launched the game, and went back into the save file I had just created to use as a test. This time, I was able to save with no issues. Didn't even need to try 'save as' or go from manage worlds > 'safe first'. No error message.
I'll hop back into my NSB save file - the one where I initially encountered the issue - and see if it now works, too, and update here with what I found. But yeah, I can confirm that like with others, so far, disabling HSY seems to have - temporarily at least - 'fixed' the bug.