Reshade works for gameplay as well, depends on how many effects you are using, the more effects you are using, the more demanding it becomes for your PC. Some effects like depth of field doesn't work at all for gameplay because you will not be able to see what you are doing so I have them bound to a shortcut key on my keyboard so I can easily turn depth of field on or off. Same goes with some bloom and lighting effects because they will make the menus impossible to read, most presets have shortcuts so you can turn those off, otherwise you have to turn them off yourself in the settings which is pretty easy to do.