no mods for me?

hello, first of want to say thank you to anyone who reaches out because I am genuinely saddened and stressed at this point. 

I have had mods for atleast 4 years and I've always used the same mods. I use more cc than anything (clothes, hair, tattoos). I have some script mods MC and xml but I always regularly update and never have any issues. Recently Ive been trying to open my game and its been giving the message "not responding' so I don't think that's crashing but it is definitely not opening. I have tried to open without. It works fine. I open with some mods, works fine. I open with entire amount or at least I try to get to the amount I used to have and in between my tests to make sure they are still working turn outs, they are not. Ive tried this in many orders which led me to try all of the same mods over and over with my game. In the end same result. I have my mods on my external hard drive they have always been so I can have 2TBs of space. My game is also on there to spare my little MacBook Air.  My game is up to date and repaired. And I use Gametime dev for my mod management, I have deleted all my mods and cleaned my game files out for a fresh start. I just want a couple of mods nothing to crazy but it sort of seems impossible at this point. Is it just not for me? Should I give up and play base game or quit sims 4 all together? Please help. Thank you again for reading!