@ineshi93
Thank you for noting you've tried checking your anti-virus.
From what I understand it's that windows or possibly origin that flags Sims 4 as already open/running, when in reality it's not. Here are some other tips I have put together for this issue.
1. Fully exit out of the game and Origin. - If exiting Origin isn't working, open Task manager (Ctrl-Shift-Esc) search for a file called ts4.exe. Click on it and select end process.
2. Fully shut down your computer, and turn it back on and try launching the game again.
3. Clear Origin Cache - https://help.ea.com/en-us/help/faq/clear-cache-to-fix-problems-with-your-games/
4. Try uninstalling/reinstalling Origin. - https://help.ea.com/en-us/help/origin/origin/manually-uninstalling-origin/
You won't loose any Sims 4 user files, as the game install files as well as Origin install files get placed into their own install folder, separate from the documents folder. However, if concerned about this, copy the Sims 4 folder from the Documents folder to the desktop or USB key.
Installing Origin - https://help.ea.com/en-us/help/origin/origin/install-origin/
5. Run Ccleaner and it's registry cleaner to clear up any temporary, internet cache and other files that are left behind that are not being used.
Ccleaner - Free version works well for this. https://www.piriform.com/ccleaner/download
How to use CCleaner to fix PC issues - https://help.ea.com/en-us/help/pc/how-to-use-ccleaner-to-fix-pc-issues/
6. Make sure that Origin does not automatically open when starting Windows. - In Origin - Application Settings - Start-up options - turn this off. It's on by default and can cause issues, like Origin thinking games are open when they aren't.
7. Make sure Origin is Running as Administrator - Right-click on the Origin desktop icon and select Run as Administrator.
More tips can be found in this thread linked below:
Sims 4 Error: Already Running - https://answers.ea.com/t5/Technical-Issues-PC/Sims-4-Error-Already-Running/td-p/4630221
You mentioned opening a trouble ticket, good idea. If you get a different tip that works, please post about it? It seems different tips work for different players.