@jdanieIsson Since you covered the required VC++ runtimes, it's fine to skip that step; we can always come back to it later if necessary. Try uninstalling and reinstalling .NET Framework 3.5, and if that alone doesn't help, try completely disabling Avast. It's often not enough to set exceptions anymore—some antivirus programs have extra "features" that keep blocking aspects of the game, and the fastest way to test is to get the antivirus out of the way entirely. As long as you don't do anything else aside from opening Origin and Sims 4 while Avast is disabled, you should be perfectly safe.
It may also help to run Origin and Sims 4 as an admin: right-click on the Origin shortcut and select "Run as administrator," then with Origin open, do the same for TS4_x64.exe.
If those steps don't help, I'd like to see a dxdiag. And just in case there are other releated errors, please also check the Reliability Monitor. Click Windows key-R and enter "perfmon /rel" without quotes, and you'll see a chart of errors and updates with a column for each day.
For the past couple days, look for errors with a timestamp around when you've tried to launch Sims 4, or any errors that mention Sims 4 or Origin. For each one you see, click "view technical details," copy the information into a text file (Notepad is fine), and attach that file as well. The Reliability Monitor doesn't always update right away, so if you don't see any new errors after trying to open Sims 4, please check again in an hour or two.
And I won't forget about your thread, regardless of when you have time to reply. Whenever that is, I'll see your post and keep trying to help.