@puzzleaddict I also play HP Victus with the same issue, and finally, after trying out many many many options (incl. dpi scaling, now set to 100), I found the solution to turn of the checkboxes under 'multiple displays'. Mind, I don't even have multiple displays. After this the Sims4 loaded. I then added a save file and it worked. Then added my mods back, and it still worked.
Solution found after getting and checking the error code I got after crashing and found the solution here: Solved: 135dec40:598068e4:00000078:37b26003 - Answer HQ
I attach the DXDiag ran after solving this: