"There's a problem with your game's setup" patch 1.109

Ex3o  And this is with nothing else reconnected to your computer?

Please temporarily disable your antivirus, clear the EA App's cache:

https://help.ea.com/en-us/help/faq/clear-cache-to-fix-problems-with-your-games/

and repair the game (game library > Sims 4 > Manage > Repair), even if you've done it before.  Then try to play with your AV still disabled.  As long as you don't do anything else at the same time, your computer should be safe.  Reenable the AV when you're done.  If this works, add exceptions for TS4_x64 and TS4_Launcher_x64, plus EADesktop.exe.

If this doesn't help, please let me know where the game is installed, which you can see under Sims 4 > Manage > View properties.

The next step would be to try playing in a clean boot:

https://support.microsoft.com/en-us/topic/how-to-perform-a-clean-boot-in-windows-da2f9573-6eec-00ad-2f8a-a97a1807f3dd

The one service to leave enabled is the EABackgroundService, which the EA App needs in order to run.  Disable the rest as described.

When you reboot your computer, go through the Task Manager's background processes list shutting down any service that doesn't absolutely need to be running, for example anything from MSI Afterburner to RGB software might still be enabled.  If you accidentally kill a critical process and it doesn't restart on its own, just reboot your computer again.

Don't open anything other than Sims 4 and the EA App while testing, not even a browser window.

If that doesn't help either, repeat the test but with your computer offline.  You can sign into the EA App and put it in offline mode, then disable wifi and/or disconnect the ethernet cable before pressing Play.