First I couldn't click on anything once I opened the child's simology panel, I couldn't scroll down on it which was the first thing I noticed was broken, then I couldn't open her inventory, switch to...
Ideas
I cant open or interact with any of the sim panels, build buy mode or even access the save menu to exit the game
Move your Mods folder to the Desktop and delete localthumbcache.package. Then test the game in a new save.
If it works now check for updates to your Mods and CC. Add it back a little at a time while testing until you have found all that are broken.
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