I feel your pain so much, I posted about this here a couple months ago when the same thing happened to me, only I hadn't been playing my save as long as yours.
I also tried all EA fixes and everything other people suggested and nothings fixed it. It does often seem to be tied to skillful sleep, I will never give any same sex couples I play with that mastery perk, but it's not always tied to that.
It's frustrating EA doesn't even seem to be looking at the problem, I hope more people provide their save files, as well as vote on this issue!
Now I'm nervous about playing with any same sex couples, which is extra frustrating since that would be representative of myself, and representation is one of the reasons I play this game.
EA needs to do better!!