I got this problem too. Tried all methods described here, but it didn't help. So tried fixing it myself.
Firstly I updated my graphics card driver it still done no effect, so I started closing applications that were working on the background. Closed Hamachi, Remotr and Wallpaper Engine. Then started the game and it's booted normally.
I believe some background working programs can interfere with the game. I don't know what program was in my case, because now game starts normaly even if theese programs are opened.
So I hope it will help you.
Yes, I had same problem as @BananqtZ had. Game froze for a couple minutes after startup or after every match. Also since the previous season I had to wait a couple minutes for shaders to load every time I started up the game. All these problems disappeared after I closed the program named "Remoter"(Problem came back after I restarted my computer, so I found exactly what program made apex to freeze for me).
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