Games will not load?

Things to try (checking after each one to see if the problem is resolved):

Let's start with, "Did you follow the instructions found in this topic: [Information] Mass Effect 1 and Windows 7 - You need patch 1.02 to play, which is pinned at the top of this forum?"

Next, set Origin to "Run as Administrator".

Then, disable "Cloud Storage" for saves.

Now, set MassEffect Launcher.exe to run in "Windows XP (SP3) Compatibility Mode".

Lastly, if ME2 really still won't start, set MassEffect2Launcher.exe to run in "Windows XP (SP3) Compatibility Mode".

Let us know how things go!

@thandanlyman: You really need to stop pointing people to that sticky, as Origin now automatically applies that patch to new installs, and your instructions to set MassEffect Launcher.exe to run in compatibility mode are wrong because there is no such file.   You also missed the critical step of removing Origin from the system tray before trying to run it as administrator.   I probably wasted a good 45 minutes trying to follow your instructions before I found the correct procedure in the post by "theprytanis" in this thread:

http://answers.ea.com/t5/Mass-Effect/Patch-1-02-Implementation-Not-Found-Error-Run-as-Admin-doesn-t/m-p/822272#U822272

...which I copy below for quick reference:

-->Steve

-------------Begin quote---------------

@zgworts; 

Let's see...

1.  We don't know that the person has the "new" install, and they didn't indicate that they had that patch applied

2.  There is, in fact, the program MassEffectLauncher.exe on many (if not all) installations, so if it exists for a given player that fix helps. My own Win8 Pro/64-bit rig being an example.

3.  Setting the Launcher programs to compatibility mode is a step I recommended to try AFTER changing Origin to "Run as Administrator".  So if the solution you referenced were indeed adequate, then the instructions I gave (if followed) would have been as well, and the problem would have been solved before arriving at anything to do with the Launchers.

4.  And if you "wasted 45 minutes" because you didn't completely exit a program before trying to change its run settings in Windows, then I'm sorry.  But really now, I wouldn't have bothered to give instructions on how to "copy-paste" either, if that had been needed.

Lastly, if you believe that the solution you found is more appropriate than the sticky at the top of the forum that the Moderators selected, you might PM one of them and suggest that it be replaced.

Posted elsewhere by me, but here goes.  If the other fixes fail, try this :

 : COPY the disk to desktop ( just make a file for it and copy and paste the disk (for me1) into the new folder.  Then try to open the folder again, and click setup.  If that works ( and it should) click play in the new files ( in your documents folder, there should be a new mass effect folder). open that folder, and click to play.  It worked for me.  Now, MAss Effect 2 is a little harder.  YOu make the same new folder on your desktop, but when you get to the second disk pasting it in, make a new folder INSIDE your me2 folder.  Then copy the files back to the disk 1 folder by opening the disk 2 folder ( inside your disk 2 folder then press ctrla, ctrl c, then switch out of that folder into the disk 1 folder, and press ctrl v.  When prompted whether to overwrite files, etc,, make SURE that you select KEEP BOTH FILES!.  Then install ME2, and play as normal.  (It worked for me, I spent WEEKS trying all the other fixes, and this one worked for me!)