ME1-(Legendary Edition) (Remastered)- Can't Shoot

@FingerArthritis 

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spootyboy wrote:

No one post use the keyboard and mouse also. That's not helpful. 

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It is still be of interest if it works with K&M? That would narrow down the problem.

Did you tried to repair the game.

(Origin > Game Library > right click MELE > Repair)
(Steam > Game Library > right click at MELE > Properties > Local Files > Verify integrity of game files.)

I have had it happen on rare instances when playing Infiltrator on M&K, not anything like every time, maybe one out of 100 uses...or less.  It was annoying when it happened, luckily it wasn't fatal for me when it did happen.

Most of the time it took end of combat to fix it, but not every time......Didn't have it happen enough to figure any pattern, or help to diagnose it, but as a me too post, yeah, M&K it happens sometimes.

This actually happened to me on PC. I was playing on Insanity so I was fully commanding my squad who were Kaidan and Garrus most often, specced into their tech abilities to compliment an Adept Shepard- I was always running tech companions so not certain whether other abilites would set this off but it was bizarre but definitely triggers with keyboard and mouse. It would be anywhere up to a few decent heartbeats where I wouldn't be able to shoot but do everything else. 

It wouldn't frustrate me until the end of combat, however this as an Adept with absolutely no gun skills. I didn't even spec into Pistols because I could use everything.

If that helps, be aware of krogan in ME1 as they use stasis on you. It is possible that some enemies are using biotic or tech powers which disable your gun not only the use but switching too.