This would be so cool! In the beginning, when creating your sim, you could give them a disease or defect at birth or somewhere is the settings be able to turn it off. You could make them have cancer, ...
It is a creative idea, but I don't think that would be a good addition to The Sims series. Like others have said, a lot of players have dealt with the loss of a loved one or loved ones that were taken by diseases. I think that if diseases were added to The Sims, those players would be reminded of their lost loved ones and it wouldn't be a good experience. That's just my view, though.
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