If the options button does not work, and you can't save as generally the menu to load/save is separate from the current game unless it's a different bug, then I guess you have to restart. It's a repeated problem with long playtime.
For me, my cursor becomes unresponsive occasionally if I try and switch up aspirations to game the system into giving loads of points. Ex. No point in trying to paint masterpieces while I'm working on the 3rd bestseller, but when I go back to painting, try and get that 5th one. When the cursor stops working for me, the best solution is waiting it out. It is an improvement on when the cursor completely disappears after it keeps pulling up the needs when I click on the fridge or toilet, though.
