I think there would need to be purpose to the combinations, like to expand on gameplay features. Letting those packs work together better.
Life and Death, combined with vampires for example seems ideal. Like it was meant to be one expansion. Combining it could allow for some interesting new content for vampires related to morning, death and funerals. Like maybe some sims might want to prove the deceased at a funeral is not a vampire. Vampires could maybe get some very different stuff regarding the soul journey, like when becoming a vampire they could have a journey to actually obtain a soul or choose to be without.