There's currently an issue where some virus programs (namely AVG and AVAST) are blocking the user folder.

There are several symptoms currently for this issue

Taking Screenshots and Videos doesn't work as the game is unable to write them to the screenshot/recorded video folder
Mods/CC and other changes in the options stay how they currently are cause the game is unable to write the changes to the file
Gallery has red X showing instead of pictures. I assume that's the same problem as the game is unable to download the thumbnail pictures to the cache folder
GameVersion.txt shows the wrong game version

To solve this you need to add the following files as an exception to your Antivirus Program (see instructions for your particular program on how to do this).

C:\Program Files\Electronic Arts\EA Desktop\EA Desktop\EADesktop.exe
C:\Program Files\EA Games\The Sims 4\Game\Bin\TS4_x64.exe
For DX9: C:\Program Files\EA Games\The Sims 4\Game\Bin\TS4_DX9_x64.exe

Paths may vary depending on your installation.

Both Avast/AVG have sections for Ransomware. You need to add it there. Please see instructions here: Add Exceptions to Anti Virus Programs

If you are using Windows Defender, the Ransomware settings have similar effects.

Details on how to solve this here: Windows 10 Defender – Controlled Folder Access

If this doesn't help, try deleting your cache files: Delete Cache Files and move options.ini to the desktop.

If you have further issues, please state which program your using in your post.

Further suggestions