Appreciate the help. I didn't have one drive installed, but I was syncing to some folders (?) I installed OneDrive, paused syncing once it was in place, then repaired the Sims 4 file. I have not seen any change in performance, identical error when attempting launch.
My antivirus is Windows Defender.
@jasonjove Are you still having issues? You marked my post as the solution, so I'm not sure. If you still can't play though, please try disabling Controlled Folder Access:
https://crinrict.com/blog/2019/03/windows-10-defender-controlled-folder-access.html
If that doesn't help, please create a new admin Windows account and try there. Make it local, as in, don't link it to your Microsoft account. You'll be able to (try to) launch Sims 4 without reinstalling anything.
I would suggest disabling OneDrive again; it causes more problems than it solves. There's no need to pause syncing if it's not running in the first place, and the pause is more of a temporary workaround than a solution.
