I Can't play the Sims anymore

Remove Mods First if you have mods sometimes it deletes mod content before update, go back to previous save.

There was a Bug a while back that prevented you from interacting with the UI if a Sim from Get to work was saved in the middle of the active career at the active lot.  If you play more than one household check to make sure all playable households are home from their active work career.  This bug only effects households UI when the game is saved in the middle of a active work lot and exit the game or exit to menu, and load the game back up and select a different household.  This only effects rotational gameplay.  If that is not the case it may be a new bug.