@bigran512 Most likely.
This is what I recommend doing:
1. Check the external drive for any Madden NFL files and delete them.
2. Detach the drive and then check your internal drive to see if there are any Madden files. Delete all of them.
3. Power cycle the console.
4. Re-install Madden NFL 21 to the internal without the external attached.
5. Once installed, check your Xbox/Game settings to verify all post-game updates will be installed to the internal drive.
This is one issue I see with external drives. Some drives might not be fully compatible or what happens is that files will be located on both external and internal, causing performance issues.
I've seen some games simply not work the way they should on an external drive or with one attached.