I had to abandon a save I had 20 hours in because of this bug. I started up a new rook, qunari LoF rogue, and managed to make it past what triggered the bug on my previous save. Now at 18 1/2 hours in and working on map comp, I suddenly can't interact with any dagger-trigger items even though I have the dagger on my hip. This comes after a visit to Dock Town in which I did the quests involving Blight in the catacombs and the woman's missing husband, both of which caused zero issues until I moved on to Arlathan to do more map completion. When I arrived, I suddenly couldn't use the dagger for anything but companion interactions. Any dagger-trigger items that usually have lights indicating you can use them are dim -- ones I've never used before -- and are unusable. I don't have it in me to start ANOTHER new playthrough after spending so much time on this one, so here's hoping BioWare fixes this.
EDIT: I decided to restart my computer as a last-ditch effort. Loaded up my save, and the dagger was gone. I'm not touching the game until EA and BioWare can push through a fix for this. I just don't have it in me to start over for the fourth time, only for this bug to inevitably happen again.