[BUG] Can't save during most of Dossier: the Warlord (ME2)
This is an even-worse version of a quirk left over from the original. In the old version, there was a long stretch after fighting the series of Krogan on some narrow pathways at the bottom of the level (right after the tank-bred Krogan talks to you and opens up the rest of the level) where you had to go through a series of fights against mercs without being able to save in between. It was possible, however, to exit combat (and therefore save your game) by walking back toward the area where you fought the Krogan.
Now, it appears you cannot save at all, anywhere, for about the second half or more of the level. Specifically, after you fight the Krogan, you go up some stairs. You come to a room with a medkit, some power cells, and a sniper rifle upgrade. There is a door you have to open, behind which are some Blue Suns Heavies and Troopers. I believe you can save (or the game autosaves) before you open the door. But once you open the door, you are stuck in combat and cannot save for the rest of the level...even after you talk to Okeer in his lab. I tried walking all the way back to basically the beginning of the level, but it did not help. Even at times when your dead companions stand back up (indicating the end of combat), you cannot save.
This can be pretty frustrating (especially on Insanity), since you have to go through a number of fights that include a lot of Heavies who can quickly kill you with a couple of rockets. Even worse, you can't save before the final boss fight, which is fairly tough if
Granted, I only went through this once, and did not try it again to see if it happens every time. Also, this is on PC.