Hi! I also have the issue with the game not work at all not even the launcher.
Win 10 Mass effect is directly on the Origin. The patch didn't do anything.
I tried adding it to the firewall, fully disabling my antivirus and windows fire wall, I disabled Microsoft files protection thingy. I don't have the one drive protection.
I tried to launch exe of the launcher and the games itself as an administrator.
My machine is powerful however, the processors is old but still good.
I also did some minor changes that I no longer remember.
PS. I think you are God for helping everyone in the forum and I believe I speak for everyone.
@GHoST_pl2 Perhaps try giving my custom launcher a shot. It has helped some people who couldn't get the original BioWare launcher to run on older CPUs. Also make sure to turn off 'run as admin' though after you've installed it, as explained in my post and here.
EDIT: I can see from your dxdiag that you do have a CPU that lacks AVX instruction support, so the custom launcher will likely be helpful.
I was skeptical at first as I didn't think that my processor was that old (2011) just 10% slower then new Intel however, it did indeed work. I love you soo much man/woman/whatever pronoun you prefer. This game saved my life and now I can enjoy it again. Thank you soo much. I feel stupid for not trying it before. o7
