Various Bugs (PC)
ME1 -
Virmire - Talking to your squadmates (and the salarians) on the beach before the base assault has some very noticeable audio quality/volume issues. Some voice lines are a lot quieter or louder than they should be.
Corporal Toombs will speak to Shepard if they were on Akuze even if they weren't, however this doesn't affect the dialogue if Toombs shoots himself (which has unique dialogue if Shepard is a Sole Survivor).
ME2 -
On his recruitment mission, part of Garrus's face doesn't load on the scene when you check on him after he gets shot down.
Ashley doesn't mention anything about Garrus being with you/the team on Horizon if you bring him along. Normally she does.
It's possible to get stuck inside one of the doors despite being able to interact with it. I'll have to check my game-play footage where this happens.
ME3 -
If Ashley survives the Citadel coup and asks to be back on Normandy, rejecting her request and sending her Hackett instead really screws around with the private messaging system. Ash will email Shepard as if she's both on the team (suggesting meeting up on the Citadel) and with Hackett at the same time. It seems it also affects the Citadel DLC private messages, Shepard can meet up with Wrex without getting his email first.
Tali will be listed on the Presidium Commons map list (after she's recruited) but will not be actually there until after you finish the Citadel DLC mission for some reason. She will also not be listed on the map when she does actually appear (where she's talking to the turian who called her suit-rat back 3 years ago).
Leviathan DLC - If you bring Garrus (romanced) and Tali to the Mahavid asteroid mission, Garrus won't appear in the cutscene where he says "Bad vibe to these guys. I don't think we want to push it." The audio and subtitles are still there, and the camera still pans as if he was there. It plays normally providing the other squadmate (such as Liara) is the one that presses the reception button.
I'm unable to get the melee kill achievement (or any credit towards it) or the paramour II achievement in ME3. Other achievements seem to work fine, though I am not playing on Insanity.
Romance Scene with Garrus - His outfit is very broken. There seems to be missing textures and the shoulders look crumpled up. I've tried reloading the game a few times before this scene pops up but Paramour II won't pop nor does it fix his outfit.
Not that I would complain if Garrus wore pants with thigh holes, but just doesn't seem his style.